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pentobarbital will lessen the level or effect of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the extent or effect of atogepant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Advisable atogepant dosage with concomitant use of robust or average CYP